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Inflammation Part 2: The Tale of Three Stress Sensors and their Interactions:...
These articles by James Watson and Vince Giuliano are not actually research, but are such in depth background that I consider must reading to understand NAD+ This one is published here The post...
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Inflammation Part 3: resolving inflammation – resolvins, protectins, maresins...
These articles by James Watson and Vince Giuliano are not actually research, but are such in depth background that I consider must reading to understand NAD+ This one is published here The post...
View ArticleWhy NAD+ Declines during Aging: It’s Destroyed
NAD+ is required not only for life but for a long life. In this issue, Camacho-Pereira et al. (2016) implicate CD38 in the decline of NAD+ during aging, with implications for combating age-related...
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Building the Case that Aging is Controlled from the Brain
Last week, a new study came out fingering the hypothalamus as locus of a clock that modulates aging. This encourages those of us who entertain the most optimistic scenarios for anti-aging medicine....
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Mitochondria in Aging, I Mechanisms and Background
A popular theory a generation back sought to trace aging to oxidative damage originating in the mitochondria. Every cell in the body has hundreds or thousands of mitochondria, the sites of the...
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Mitochondria in Aging, II: Remedies
The once-popular mitochondrial free radical theory of aging proved to be too glib. Aging isn’t fundamentally about dispersed damage; rather, dispersed damage is a result when the body’s defenses stand...
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PCSK9 protein a major driver of inflammation in cardiovascular disease
This is the fourth in what we expect will be seven or more blog posts concerned with chronic inflammation. It relates to a recently discovered protein PCSK9 and tells a story of how age-related loss...
View ArticleBen Greenfield on NAD+
This is the transcript from Ben’s podcast you can listen to here: Ben: Hey folks, it’s Ben Greenfield, and I wanna tell you about an article I recently read in Scientific American. This article was...
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Nicotinamide Riboside fights aging liver disease in Mice
Increasing evidence about the importance NAD+ levels in the body continuous to emerge. This week reseachers in China released a report indicating a link between the onset of nonalcoholic fatty liver...
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Part 5 of the NAD world: the conflicting roles of NAMPT – inflammation or...
By James P Watson with commentary and assistance by Vince Giuliano, published here The post Part 5 of the NAD world: the conflicting roles of NAMPT – inflammation or rescue? Also Part 1 on a new series...
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